GLP-1 possesses several physiological properties that make it (and its analogs) a subject of intensive investigation as a potential treatment of diabetes mellitus. The known physiological functions of GLP-1 include: increases insulin secretion from the pancreas in a glucose-dependent manner. decreases glucagon secretion from the pancreas by engagement of a specific G protein-coupled receptor. increases insulin-sensitivity in both alpha cells and beta cells increases beta cells mass and insulin gene expression, post-translational processing and incretion. inhibits acid secretion and gastric emptying in the stomach. decreases food intake by increasing satiety in brain. promotes insulin sensitivity. As evidence of the physiological role of GLP-1 in post-prandial insulin secretion, it has been … Continue reading GLP-1